NGI Next Generation Impactor

A new cascade impactor has been designed for the OINDP Industry, specifically for pharmaceutical inhaler testing, and is the most efficient and accurate way to do standard in vitro APSD testing.

The Impactor, called the Next Generation Impactor (NGI), has seven stages and is intended to operate at any inlet flow rate between 15 and 100 L/min.

It offers a cut size (D50) spectrum spanning from 0.98 µm to 14.1 µm aerodynamic diameter at 15 L/min, 0.54 µm to 11.7 µm aerodynamic diameter at 30 L/min, 0.34 µm to 8.06 µm at 60 L/min, and 0.24 µm to 6.12 µm at 100 L/min.

The impactor’s aerodynamics adhere to well-established scientific principles, ensuring reliable particle size fractionation behavior across the designated flow range.

Specifically tailored for inhaler testing, the NGI incorporates features to enhance its utility. Notably, particles are deposited onto collection cups held in a tray that can be swiftly removed as a single unit, facilitating rapid sample turnover when multiple trays are utilized. 

For efficient drug recovery, users can introduce approximately 40 mL of a suitable solvent directly into the cups. Another distinctive feature is the micro-orifice collector (MOC), which captures extremely small particles, usually collected on the final filter in other impactors, in a dedicated collection cup.

The particles gathered in the MOC cup can be analyzed in the same manner as those collected in other impactor stage cups. With its user-friendly attributes and adherence to aerodynamic design principles, the NGI proves to be a well-suited impactor for the requirements of the inhaler testing community.